Renoprotection of angiotensin receptor blockers: beyond blood pressure lowering
نویسندگان
چکیده
منابع مشابه
Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering.
Clinical studies have demonstrated that some antihypertensive agents provide renoprotection independent of BP lowering. Recent in vitro and in vivo studies evaluated the mechanisms involved in this protection. First, the in vitro effects of several angiotensin II type 1 receptor blockers (ARB), calcium channel blockers (CCB), and beta blockers (BB) on various mediators were compared: Formation ...
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H ypertensive patients have an excess of other cardiovascular risk factors, including hyperlipidaemia. Because various antihypertensive drugs, especially diuretics and beta blockers, adversely affect lipid metabolism, these drugs may increase associated risks for coronary artery disease and thus offset some of the beneficial effects of blood pressure reduction. The renin angiotensin system is a...
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Angiotensin-II (Ang-II) activates two major types of receptors, angiotensin II type one (AT1R) and type two (AT2R) receptors. While AT1R is widely expressed and mediates most inflammatory Ang-II effects, AT2R, is less expressed and has opposite effects, promoting vasodilation and anti-inflammatory effects . Physiologically, AT2R actions are usually masked by the more abundant AT1R. It has been ...
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Angiotensin receptor blockers (ARBs) have become established as a major class of antihypertensive on the basis of their powerful effects on blood pressure (BP), excellent tolerability and pleiotropic end-organ-protective effects. However, individual ARBs vary in antihypertensive efficacy, which may be important to clinical outcome. Several strategies are available to ensure that BP reductions w...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2006
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfl013